Combination of Lamivudine and adefovir therapy in HBeAg-positive chronic hepatitis B patients with poor response to adefovir monotherapy
β Scribed by L.-C. Wang; E.-Q. Chen; J. Cao; L. Liu; J.-R. Wang; B.-J. Lei; H. Tang
- Book ID
- 108886315
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 111 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1352-0504
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Although adefovir dipivoxil (ADV) has a unique profile of delayed and infrequent resistance in treatment-naΓ―ve chronic hepatitis B patients, the association of ADV resistance with previous lamivudine (LAM) resistance is not well understood. We compared the emergence of the ADV-resistant mutations rt
We studied the long-term efficacy of adefovir dipivoxil (ADV) treatment in 42 HBeAgnegative patients with chronic hepatitis B (CHB) who had developed genotypical lamivudine (LAM) resistance with virological and clinical breakthroughs under long-term LAM treatment. Patients were allocated in 2 treatm
## Abstract No study has reported on the comparative effect of adefovir (ADV) addβon lamivudine (LAM) versus switching to entecavir (ETV) in LAMβresistant patients with chronic hepatitis B. From October 2007 to September 2008, 92 consecutive LAMβresistant patients were enrolled (47 LAMβ+βADV and 45
This study evaluated the efficacy of adefovir (ADV) plus lamivudine (LAM) or ADV add-on therapy for patients with entecavir (ETV)-refractory hepatitis B infection. Twenty-nine ETVresistant and 8 patients with suboptimal response to ETV were enrolled. Twenty-seven patients received ADV ΓΎ LAM therapy