𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Comparison of s-phase fraction, working formulation, and kiel classification in non-Hodgkin's lymphoma

✍ Scribed by Heikki Joensuu; Pekka J. Klemi; Karl-Ove Söderström; Sirpa Jalkanen

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
682 KB
Volume
68
Category
Article
ISSN
0008-543X

No coin nor oath required. For personal study only.

✦ Synopsis

The prognostic value of S-phase fraction (SPF), determined by flow cytometric study from paraffin-embedded tissue, and grading by Working Formulation (WF) and Kiel classification were compared among 245 patients with non-Hodgkin's lymphoma followed for the median of 89 months or until death. Histologic reclassification and SPF determinations were done without knowledge on clinical data. SPF (P equals 0.0001), WF (P equals 0.0003), and Kiel classification (P equals 0.0008) were associated with mortality in lymphoma in a univariate analysis, and WF and SPF were independent prognostic factors in Cox's multivariate analysis. Although SPF correlated strongly both with WF and Kiel grades (P less than 0.0001), low-grade and high-grade malignant lymphomas according to Kiel classification, and high-grade lymphomas according to WF could be divided into groups with significantly different outcome by SPF. The results suggests a role for SPF in therapeutic decision-making.

📜 SIMILAR VOLUMES

Distinctive clinical features between ly
Distinctive clinical features between lymphoblastic and immunoblastic non-Hodgkin's malignant lymphomas (Kiel's classification) in a series of 141 patients
✍ B. Hórni; Monique Trojani; H. Eghbali; M. Durand; J. M. Coindre; P. Richaud; Gen 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 322 KB

Out of a series of 427 NHML based on the Kiel classification and without previous treatment, 186 were of high grade malignancy and among them were 83 lymphoblastic (LB) and 58 immunoblastic (IB) lymphomas which were included in this study. The LB and IB, which represent the majority of high grade NH

Working formulation of the non-Hodgkin's
Working formulation of the non-Hodgkin's lymphomas: A study of cell size and mitotic indices in cytologic subtypes
✍ Dr. Dilip K. Das; Subhash K. Gupta; Bhoopendra N. Datta; Suresh C. Sharma 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 469 KB

Cell size and mitotic indices were studied in 243 nonHodgkin 's lymphomas (NHL) diagnosed cytologically and classijied according to the Working Formulation. LOW; intermediate-, and highgrade lymphomas constituted 14.8%. 18.9%, and 61.7% of the cases, respectively. Measurement of the diameter of 100