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Comparison of Physicochemical and Biological Properties of ( o -Carboran-1-YL)methylphosphonate and Methylphosphonate Oligonucleotides

✍ Scribed by Lesnikowski, Zbipniew J.; Lloyd, Robert M.; Schinazi, Raymond F.


Book ID
127377925
Publisher
Taylor and Francis Group
Year
1997
Tongue
English
Weight
204 KB
Volume
16
Category
Article
ISSN
0732-8311

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The synthesis of the (Y and p anomers of the title compound (1) was accomplished from o-mannose. In the key step, the phosphonate analogues of the mannopyranosyl phosphates were prepared by a direct Wadsworth-Emmons condensation of a protected mannose derivative (8) with tetraethyl methylenebisphosp