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Comparison of phenotypic assessment and the use of two restriction fragment length polymorphisms in the diagnosis of the carrier state in haemophilia B

โœ Scribed by D. P. Lillicrap; M. B. Liddell; R. J. Matthews; I. R. Peake; A. L. Bloom


Book ID
114710796
Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
575 KB
Volume
62
Category
Article
ISSN
0007-1048

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Restriction fragment length polymorphism
โœ B. Carritt ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Springer ๐ŸŒ English โš– 391 KB

A restriction fragment length polymorphism in the D7S1 region of chromosome 7 is detected by hybridizing the recombinant plasmid pA2H3 to HindIII- or HinfI-digested human DNA. Three HindIII and two HinfI alleles were detected, and it was found that all individuals carrying the variant HinfI allele a