Comparison of Native E. coli and PEG Asparaginase Pharmacokinetics and Pharmacodynamics in Pediatric Acute Lymphoblastic Leukemia
โ Scribed by Panetta, J C; Gajjar, A; Hijiya, N; Hak, L J; Cheng, C; Liu, W; Pui, C H; Relling, M V
- Book ID
- 109845747
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 338 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0009-9236
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๐ SIMILAR VOLUMES
Hypersensitivity to asparaginase is common, but the differential diagnosis can be challenging and the diagnostic utility of antibody tests is unclear. We studied allergic reactions and serum antibodies to E. coli asparaginase (Elspar) in 410 children treated on St. Jude Total XV protocol for acute l
Background. Escherichia coli asparaginase is an active antileukemia agent in the treatment of childhood acute lymphoblastic leukemia. Allergic reactions occurred in 31 of 125 patients (24.8%) treated with weekly high-dose (25,000 IU/m2) intramuscular E. coli asparaginase and necessitated discontinua