Hypersensitivity to asparaginase is common, but the differential diagnosis can be challenging and the diagnostic utility of antibody tests is unclear. We studied allergic reactions and serum antibodies to E. coli asparaginase (Elspar) in 410 children treated on St. Jude Total XV protocol for acute l
Clinical utility and implications of asparaginase antibodies in acute lymphoblastic leukemia
β Scribed by Liu, C; Kawedia, J D; Cheng, C; Pei, D; Fernandez, C A; Cai, X; Crews, K R; Kaste, S C; Panetta, J C; Bowman, W P; Jeha, S; Sandlund, J T; Evans, W E; Pui, C-H; Relling, M V
- Book ID
- 119980295
- Publisher
- Nature Publishing Group
- Year
- 2012
- Tongue
- English
- Weight
- 303 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0887-6924
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## Abstract ## BACKGROUND. Rapid clearance of poly(ethylene glycol)βasparaginase (PEGβASNase) has been reported for up to oneβthird of patients treated for acute lymphoblastic leukemia (ALL), potentially rendering their treatment ineffective. A 25% occurrence of an antibody against PEG (antiβPEG)
Two groups of children with refractory acute lymphoblastic leukemia were treated with a regimen of methotrexate (MTX) and asparaginase (Asn'ase) based on studies of the effect of MTX in vitro on human lymphoblasts exposed to Asn'ase. Induction therapy in 12 children produced 4 complete remissions, 3