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Comparison of losses of heterozygosity and replication errors in primary colorectal carcinomas and corresponding liver metastases

✍ Scribed by Bl�ker, Hendrik; Graf, Matthias; Rieker, Ralf J.; Otto, Herwart F.

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
267 KB
Volume
188
Category
Article
ISSN
0022-3417

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✦ Synopsis

In order to investigate genetic alterations specific to liver metastases of colorectal carcinomas, losses of heterozygosity and replication errors have been compared in 15 cases of primary colorectal carcinoma and in the corresponding metastatic liver tumours. Fifteen microsatellite markers located on 13 different chromosomal arms were used in the study. The LOH patterns of the primary and the metastatic tumours were identical in eight cases and showed differences in seven cases. Areas of deletion predominantly or completely common to the colorectal and the metastatic tumour were detected on chromosomes 5q, 8p, 17p, 18q, and 22q. Preferential loss in metastatic tumours was observed on chromosomal arm 3p. Replication errors were found in four primary tumours and in three of the corresponding secondaries. A replication error phenotype specific to a metastasis was not observed.

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