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Comparison of gas—liquid chromatography and fluorescence polarization immunoassay for therapeutic drug monitoring of flecainide acetate

✍ Scribed by C.M. Stas; P.A. Jacqmin; P.L. Pellegrin

Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
380 KB
Volume
7
Category
Article
ISSN
0731-7085

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✦ Synopsis

A gas chromatographic (GC) method for quantitation of flecainide acetate in human plasma is described and compared with a fluorescence polarization immunoassay (FPIA) for therapeutic drug monitoring. The GC method includes a solid-phase extraction procedure and electron capture detection (ECD) without the need of derivatization. Within-day and between-day coefficients of variation were less than 7% of GC and FPIA. Recovery was between 89-101% for the GC method. Plasma from 36 patients were analysed by both GC and FPIA and the results showed a good correlation (slope = 0.96; intercept = 0.009 micrograms ml-1; r = 0.987).

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