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Comparison of FAIR perfusion kinetics with DSC-MRI and functional histology in a model of transient ischemia

✍ Scribed by Janneke Schepers; Wouter B. Veldhuis; Robert-Jan Pauw; Jan-Willem de Groot; Matthias J.P. van Osch; Klaas Nicolay; Boudewijn P.J. van der Sanden

Book ID
102529091
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
352 KB
Volume
51
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Flow‐sensitive alternating inversion recovery (FAIR) is a noninvasive method for perfusion imaging. It has been shown that the FAIR signal may depend on hemodynamic parameters other than perfusion, the most important one being transit delays of labeled spins to the observed tissue. These parameters are expected to change with ischemia. The goal of this study was to assess the effect of these changes on the interpretation of FAIR results in the case of altered perfusion. This was investigated in a rat model of transient cerebral ischemia. It was shown that the ratio of FAIR signal in the infarct compared to the contralateral side was lower at short inflow times, which suggests that transit times affected the effective FAIR signal. The FAIR results were compared with those from functional histology and dynamic susceptibility contrast MRI, and the findings indicated that the altered kinetics of the FAIR signal were related to reduced and delayed inflow in the infarct regionβ€”not to a decrease in the number of functional vessels. Magn Reson Med 51:312–320, 2004. Β© 2004 Wiley‐Liss, Inc.

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