Comparison of ECS and flurothyl-induced retrograde amnesia in mice

✍ Scribed by Z. Bohdanecky; R. Kopp; M. E. Jarvik

• Publisher: Springer
• Year: 1968
• Tongue: English
• Weight: 293 KB
• Volume: 12
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00401537

✦ Synopsis

have demonstrated a gradient of what is commonly referred to as retrograde amnesia (l%A) from electroconvulsive shock (ECS) in a one-trial passive avoidance situation in mice and rats with varying temporal characteristics. Retrograde amnesia has also been produced by treatments other than ECS such as barbiturates, ether, pentylenetetrazol (PA~, 1961; PWAl~LNAN et al., 1961; I-Iv,~z et al., 1966) and spreading depression (Bm~Es and Bvm~sovA, 1963; PEa_RL-NAN, 1966) ; however, little is known of how the learning trial-treatment time interval is related to the RA effect of these treatments.

The present study is an attempt to produce a temporal gradient of l%A by a treatment other than ECS and to compare its characteristics with that obtained from ECS. Flurothyl (hexafluorodiethyl ether) is a powerful inhalant eonvulsant agent comparable to ECS in its general behavioral and physiological properties (K~ANTZ et al., 1957), but a detailed systematic study of its amnestic qualities has not yet been done.