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Comparison of D2O and ethanol dilutions in total body water measurements in humans

✍ Scribed by Endres, H.G.E. ;Gr�ner, O.

Publisher
Springer-Verlag
Year
1994
Tongue
English
Weight
770 KB
Volume
72
Category
Article
ISSN
1432-1440

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✦ Synopsis

Total body water was measured by ethanol dilution and D20 stable isotope dilution in a group of 20 healthy volunteers (5 females and 15 males), predominantly 23-to 31-year-old students. Both indicator substances were given orally with an ethanol burden of 0.8 g/kg body weight and a D20 burden of 0.1 g/kg body weight after 12-h food and fluid restriction. This first direct comparison of total body water (TBW) from ethanol and D20 dilutions revealed the ethanol compartments to be smaller than those of D20. The quotient of TBW (ethanol)/TBW (D20) was 97.7% , which is the order of the quotient TBW (H2180)/TBW (D20) (= 97%), well known from the literature and taken to represent relatively exactly the value of TBW overestimation (based on H/D exchange for acid protons) following D20 dilution . Thus the value of TBW (ethanol) is almost identical to that of H 180 2 , which provides direct evidence that ethanol is distributed only in the body water.

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