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Comparison of cytochrome P-450 levels in adult rat liver, postnatal rat liver, and primary cultures of postnatal rat hepatocytes

✍ Scribed by Daniel Acosta; David C. Anuforo; Reagan McMillin; William H. Soine; Robert V. Smith


Book ID
118939221
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
364 KB
Volume
25
Category
Article
ISSN
0024-3205

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Dimethylnitrosamine genotoxicity in rat
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Liver primary cell cultures (LPCC) with decreasing concentrations of cytochrome P-450 were used to investigate the genotoxicity of the hepatic carcinogen dimethylnitrosamine (DMN) and the correlation between DMN genotoxicity and cytochrome P-450 levels. Hepatocytes were isolated from partially hepat