Characteristics of familial aggregation of Alzheimer's Disease were studied in 92 families ascertained through a clinically diagnosed proband with an onset below age 60 years. In each family data were systematically collected on the sibships of the proband, of his father, and of his mother. A total
Comparison of clinical characteristics between familial and non-familial early onset Alzheimer’s disease
✍ Scribed by Joshi, Aditi; Ringman, John M.; Lee, Albert S.; Juarez, Kevin O.; Mendez, Mario F.
- Book ID
- 118784356
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 237 KB
- Volume
- 259
- Category
- Article
- ISSN
- 0340-5354
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## Abstract The effect of the apolipoprotein E (APOE) ϵ4 allele on age of onset was analyzed in two groups of families with early‐onset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) early‐onset non‐VG families showing evidence of linkage