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Comparison of cisplatin and carboplatin cytotoxicity in human ovarian cancer cell lines using the MTT assay

โœ Scribed by James Fanning; William C. Biddle; Martin Goldrosen; Kent Crickard; Ulla Crickard; M.Steven Piver; Kenneth A. Foon

Book ID
119053725
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
352 KB
Volume
39
Category
Article
ISSN
0090-8258

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## Abstract The clinical efficacy of cisplatinโ€based chemotherapy for ovarian cancer is frequently compromised by drug resistance or doseโ€limiting renal and neurologic toxicities. CIโ€973 (NKโ€121), a 2โ€methylโ€1, 4โ€butanediamine analogue of carboplatin, has shown little nephroโ€and neuroโ€toxicity in p