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Comparison of cisplatin and carboplatin cytotoxicity in human ovarian cancer cell lines using the MTT assay

โœ Scribed by J Fanning; WC Biddle; M Goldrosen; K Crickard; U Crickard; MS Piver; KA Foon

Book ID
118890197
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
140 KB
Volume
36
Category
Article
ISSN
0020-7292

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โœ R. P. Perez; P. J. O'Dwyer; L. M. Handel; R. F. Ozols; T. C. Hamilton ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 528 KB

## Abstract The clinical efficacy of cisplatinโ€based chemotherapy for ovarian cancer is frequently compromised by drug resistance or doseโ€limiting renal and neurologic toxicities. CIโ€973 (NKโ€121), a 2โ€methylโ€1, 4โ€butanediamine analogue of carboplatin, has shown little nephroโ€and neuroโ€toxicity in p