Interleukin-6 (IL-6) levels are markedly increased in the synovial fluid of patients with rheumatoid arthritis or osteoarthritis. However, the effects of IL-6 on proliferation and proteoglycan metabolism in articular cartilage are not known. We demonstrated here the effects of human recombinant (hr)
Comparison of cellular response in bovine intervertebral disc cells and articular chondrocytes: effects .of lipopolysaccharide on proteoglycan metabolism
โ Scribed by Yoichi Aota; Howard S. An; Yoshiyuki Imai; Eugene J. Thonar; Carol Muehleman; Koichi Masuda
- Book ID
- 106139155
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- English
- Weight
- 257 KB
- Volume
- 326
- Category
- Article
- ISSN
- 0302-766X
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## Abstract The intervertebral disc is the largest asvacular structure in the body; consequently, there are steep gradients in O~2~ concentration, with PO~2~ falling to as low as 1% O~2~ in the centre of the disc. We investigated the effect of O~2~ concentration on the rates of O~2~ consumption, la
Chondrocytes experience a dynamic extracellular osmotic environment during normal joint loading when fluid is forced from the matrix, increasing the local proteoglycan concentration and therefore the ionic strength and osmolarity. To exist in such a challenging environment, chondrocytes must possess