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Comparison of cefoperazone and mezlocillin with imipenem as empiric therapy in febrile neutropenic cancer patients

✍ Scribed by Joanne Mortimer; Sheree Miller; Douglas Black; Karl Kwok; William M. Kirby

Book ID
115682176
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
467 KB
Volume
85
Category
Article
ISSN
1555-7162

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## Abstract Amikacin (600 mg/m^2^/day IV) and ticarcillin (12 gm/m^2^/day IV) were administered to 38 children with cancer, neutropenia (< 1,000 PMN/mm^3^), and fever (β‰₯ 38Β°C) during 46 febrile episodes. Sixty‐one percent of the children were severely neutropenic (<200 PMN/mm^3^). Febrile episodes

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## BACKGROUND. The improved efficacy of imipenem over other beta-lactam antibiotics in the treatment of febrile neutropenic patients has been attributed to its broad spectrum of activity. METHODS. A prospective, randomized, clinical trial was performed comparing vancomycin 1 g every 12 hours plus