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Comparison of cardiac electrophysiological and mechanical effects of torsadogens in the isolated normal and failing rabbit hearts

✍ Scribed by Anusak Kijtawornrat; Suwanakiet Sawangkoon; Carlos Del Rio; Robert L. Hamlin

Book ID
118503572
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
55 KB
Volume
66
Category
Article
ISSN
1056-8719

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Endothelin (ET-1) is found at elevated concentrations in the plasma of patients with heart failure and in animal models of cardiomyopathy. The peptide is a potent positive inotropic agent, the effects of which are mediated by increases in cytosolic Ca2+ in cardiomyocytes. The object of this study wa