Mechanical effects of ET-1 in cardiomyoc
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Elizabeth J. Kelso; Robert F. Geraghty; Barbara J. McDermott; Elisabeth R. Trimb
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Article
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1996
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Springer
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English
โ 687 KB
Endothelin (ET-1) is found at elevated concentrations in the plasma of patients with heart failure and in animal models of cardiomyopathy. The peptide is a potent positive inotropic agent, the effects of which are mediated by increases in cytosolic Ca2+ in cardiomyocytes. The object of this study wa