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Comparison of behavioral and psychological symptoms in early-onset and late-onset Alzheimer's disease

✍ Scribed by Yasutaka Toyota; Manabu Ikeda; Shunichiro Shinagawa; Teruhisa Matsumoto; Naomi Matsumoto; Kazuhiko Hokoishi; Ryuji Fukuhara; Tomohisa Ishikawa; Takaaki Mori; Hiroyoshi Adachi; Kenjiro Komori; Hirotaka Tanabe

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
94 KB
Volume
22
Category
Article
ISSN
0885-6230

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✦ Synopsis

Abstract

Background

When comparing with early‐onset Alzheimer's disease (EO‐AD) and late‐onset Alzheimer's disease (LO‐AD), some symptomatological differences in clinical features can be seen between them. Rapid progression, more severe language problems or visuospatial dysfunction occur more often in EO‐AD patients. However, there have been very few reports about the differences in behavioral and psychological symptoms between these two groups.

Aim

The aim of this study was to demonstrate the differences in behavioral symptoms between EO‐AD and LO‐AD groups.

Method

Three hundred and seven consecutive outpatients with AD were put into an EO‐AD group (46 patients) or a LO‐AD group (261 patients). Comprehensive assessment batteries, including the Neuropsychiatric Inventory (NPI), were administered at the first medical assessment.

Results

Significant differences were found between the EO‐AD and LO‐AD groups in terms of NPI total score (EO‐AD: 10.3 ± 10.9, LO‐AD: 17.8 ± 17.0, p = 0.004) and number of patients who experienced each NPI subscale score (delusion; EO‐AD: 13.0%, LO‐AD: 50.6%, p < 0.001). There were no differences in cognitive functions or dementia severity between two groups.

Conclusion

In EO‐AD, behavioral and psychological symptoms are relatively fewer than LO‐AD at the first medical assessment. Copyright © 2007 John Wiley & Sons, Ltd.

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