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Comparison of antithrombotic and haemorrhagic effects of edoxaban, an oral direct factor Xa inhibitor, with warfarin and enoxaparin in rats

✍ Scribed by Morishima, Yoshiyuki; Honda, Yuko; Kamisato, Chikako; Tsuji, Naoki; Kita, Akemi; Edo, Naoko; Shibano, Toshiro

Book ID: 118062306
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 827 KB
Volume: 130
Category: Article
ISSN: 0049-3848
DOI: 10.1016/j.thromres.2012.05.008

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## Abstract The antithrombotic effects of YM466, a synthetic direct inhibitor of human factor Xa (FXa), were evaluated in an arterio‐venous shunt thrombosis model in squirrel monkeys. YM466 significantly inhibited thrombus formation after continuous IV zx infusion at doses of 3–30 µg/kg/h. Although