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Comparison of a new antidepressive, lofepramine, with imipramine in a double-blind multicentre trial

✍ Scribed by B. Woggon; J. Angst; M. Bleuler; Th. L. J. Dittmer; K. Heinrich; H. Hippius; H. Martens; I. Seibel

Publisher
Springer-Verlag
Year
1975
Tongue
English
Weight
335 KB
Volume
221
Category
Article
ISSN
1433-8491

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✦ Synopsis

Lofepramine, an imipramine derivative, shows lower acute toxicity in animals when compared with desipramine and imipramine. Its anticholinergic effect is less pronounced than that of desipramine. In an open clinical trial lofepramine showed a marked antidepressive action. A double-blind multicenter trial of lofepramine v. imipramine, evaluated by means of the AMP system, showed a remarkable degree of concurrence with regards to the effects of those two products.

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