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Comparison of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD)- and 1R,3S-ACPD-stimulated brain phosphoinositide hydrolysis

✍ Scribed by Darryle D. Schoepp; Bryan G. Johnson; Rebecca A. True; James A. Monn


Book ID
113398149
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
305 KB
Volume
207
Category
Article
ISSN
0922-4106

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## Abstract Amino acids 1 and 2 were designed and synthesized as the conformationally constrained analogues of (1__S__, 3__R__)‐ or (1__S__, 3__S__)‐ACPDs, and the selective agonists of mGluRs. The synthesis started from (__R__)‐phenylglycine using Seebachβ€²s stereocenter self‐regeneration method an