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Synthesis and biological activity of l-aminoindan-l,3-dicarboxylic acid, a benzo-analogue of (1S, 3R)-ACPD

✍ Scribed by Ke Ding; Xin-Rong Zhang; Da-Wei Ma; Bao-Min Wang

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
460 KB
Volume
19
Category
Article
ISSN
0256-7660

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✦ Synopsis

Abstract

Amino acids 1 and 2 were designed and synthesized as the conformationally constrained analogues of (1__S__, 3__R__)‐ or (1__S__, 3__S__)‐ACPDs, and the selective agonists of mGluRs. The synthesis started from (R)‐phenylglycine using Seebachβ€²s stereocenter self‐regeneration method and intramolecular acylation as key steps. No activity was found when 1 and 2 were tested as either mGluR agonist or antagonist.

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