Comparison between cobalt and pyrazole in the increased expression of coumarin 7-hydroxylase in mouse liver
β Scribed by Zeliha Kocer; Hannu Raunio; Markku Pasanen; Pentti Arvela; Tero Raiskila; Paavo Honkakoski; Matti A. Lang; Masahiko Negishi; Olavi Pelkonen
- Book ID
- 115782375
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 435 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0006-2952
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## Abstract A high level of Cyp2aβ5 was found in spontaneous and transplanted mouse hepatomas compared with normal liver. Increased expression of Cyp2aβ5 was associated with an increase in coumarin 7βhydroxylation, a marker activity of Cyp2aβ5, and the corresponding mRNA, suggesting that regulation
Cholesterol 7a-hydroxylase (CYP7A1) is the rate-limiting enzyme in the bile acid biosynthetic pathway that converts cholesterol into bile acids in the liver. Recent studies have shown that bile acids may play an important role in maintaining lipid, glucose, and energy homeostasis. However, the role