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Comparing experimental designs for benchmark dose calculations for continuous endpoints

โœ Scribed by Kristi Kuljus; Dietrich von Rosen; Salomon Sand; Katarina Victorin


Book ID
119378505
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
68 KB
Volume
164
Category
Article
ISSN
0378-4274

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## Abstract We introduce a new optimal design for dose finding with a continuous efficacy endpoint. This design is studied in the context of a flexible model for the mean of the doseโ€“response. The design incorporates aspects of both __D__โ€ and __c__โ€optimality and can be used when the study goals u