Comparative study of the immunogenicity and safety of two doses of recombinant hepatitis B vaccine in healthy adolescents
β Scribed by Gilbert M. Schiff; James R. Sherwood; Jerome B. Zeldis; David S. Krause
- Book ID
- 116173325
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 394 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1054-139X
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A hepatitis B vaccine produced in yeast by recombinant DNA technology was evaluated using 5-micrograms and 10-micrograms doses in a randomized trial lasting 7 months in 110 male armed forces recruits aged 17-19 years. Results were compared to those of an identical trial of a plasma-derived vaccine.
We tested the safety and long-term immunogenicity of two of the early investigative lots of a recombinant-yeast-derived hepatitis B vaccine in immunocompetent adults. Three 10-micrograms doses of recombinant hepatitis B vaccine (Merck Sharp & Dohme Research Laboratories, West Point, PA) were adminis