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Comparative Study Analyzing Effects of Sirolimus–Cyclosporin and Sirolimus–Tacrolimus Combinations on Bile Flow in the Rat

✍ Scribed by Michael Deters; Kilian Nolte; Gabriele Kirchner; Klaus Resch; Volkhard Kaever


Book ID
110307650
Publisher
Springer US
Year
2001
Tongue
English
Weight
159 KB
Volume
46
Category
Article
ISSN
0163-2116

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The enhancing effects of cyclodextrins (CyDs) on the solubility, the dissolution rate, and the bioavailability of tacrolimus after oral administration to rats were examined and compared with those after administration of a PROGRAF 1 capsule containing the solid dispersion formulation of tacrolimus.