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Comparative studies on the covalent binding of the carcinogen benzo(a)pyrene to DNA in various model systems

✍ Scribed by W. Jaggi; W. K. Lutz; Ch. Schlatter

Book ID
112659855
Publisher
Springer
Year
1979
Tongue
English
Weight
259 KB
Volume
35
Category
Article
ISSN
1420-682X

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πŸ“œ SIMILAR VOLUMES

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The importance of intercalation in the covalent binding of benzo(a)pyrene diol epoxide to DNA
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The primary mode of non-covalent interaction of the strong carcinogen, benzo(a)pyrene diol epoxide, with DNA is through intercalation. It has variously been suggested that intercalative complexes may be prerequisite for either covalent binding or DNA-catalysed hydrolysis of the epoxide or both. Geac

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The role of 9-hydroxybenzo(a)pyrene in the microsome mediated binding of benzo(a)pyrene to dna
✍ H. W. S. King; M. H. Thompson; P. Brookes πŸ“‚ Article πŸ“… 1976 πŸ› John Wiley and Sons 🌐 French βš– 523 KB

## Abstract A study of the liver microsome‐mediated binding to added DNA of the phenol metabolites of benzo (a)‐pyrene (BP‐OH) and of 7,8‐dihydro‐7,8‐dihydroxybenzo (a)pyrene (BP‐7,8‐diol) suggested that as in the case of BP itself the reaction was catalysed by the enzyme aryl hydrocarbon hydroxyla