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Comparative Studies on in Vitro Methods for Evaluating in Vivo Function of MDR1 P-Glycoprotein

✍ Scribed by Yasuhisa Adachi; Hiroshi Suzuki; Yuichi Sugiyama

Book ID
110321341
Publisher
Springer US
Year
2001
Tongue
English
Weight
361 KB
Volume
18
Category
Article
ISSN
0724-8741

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## Abstract ## Objective To evaluate the effect of duloxetine (DLX) on the P‐glycoprotein (P‐gp) function __in vitro__ and __in vivo__. ## Method __In vitro__ experiment was conducted using the Caco‐2 cell, a human colon cancer cell line that naturally expresses the P‐gp and P‐gp function was ev