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Comparative sequence analysis of duck and human hepatitis B virus genomes

✍ Scribed by Rolf Sprengel; Christa Kuhn; Hans Will; Heinz Schaller

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 772 KB
Volume: 15
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890150402

No coin nor oath required. For personal study only.

✦ Synopsis

We have cloned and sequenced an infectious, functionally active genome of a duck hepatitis B virus (DHBV). It is 3,021 base pairs (bp) in length and shows little DNA sequence homology to the genome of human hepatitis B virus (HBV).

However, the amino acid sequences of predicted viral gene products are similar between DHBV and HBV, and the genome organization present in DHBV reflects that of HBV. As in the mammalian virus the long minus strand of the DHBV genome encodes three long overlapping reading frames designated as P, S, and C. The fourth open reading frame, termed X, is absent in DHBV. A comparison with a sequence of a second DHBV isolate [Mandart et al, Journal of Virology 49:782-792, 19841 revealed a nucleotide sequence variation of 5.6% and confirmed the presented overall gene organization of DHBV.

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