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Comparative restriction endonuclease analysis of varicella-zoster virus clinical isolates

✍ Scribed by M. Takayama; N. Takayama; Y. Kameoka; K. Hachimori; K. Kaneda; M. Minamitani

Publisher
Springer-Verlag
Year
1989
Tongue
English
Weight
823 KB
Volume
178
Category
Article
ISSN
0300-8584

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✦ Synopsis

The DNAs of 67 isolates of varicella-zoster virus (VZV) obtained from 31 individuals were compared by restriction endonuclease analysis using BamHI, EcoRI, PstI and Sinai. All of the epidemiologically unrelated 26 isolates could be differentiated using SmaI and another one or two enzymes. However, the DNA cleavage profiles of multiple VZV isolates from the same patient and the isolates from a group of patients who were infected with VZV from the same source were found to be identical to each other, as reported previously. No patients were found who were simultaneously infected with different VZV strains. Moreover, VZV showed no change in DNA fragment profiles after serial passages not only through human embryonic lung cells but also through patients.

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