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Inhibition of clinical isolates of human cytomegalovirus and varicella zoster virus by PNU-183792, a 4-oxo-dihydroquinoline

✍ Scribed by Mary L. Knechtel; Audris Huang; Valerie A. Vaillancourt; Roger J. Brideau

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 53 KB
Volume: 68
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.10193

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✦ Synopsis

The susceptibility of human cytomegalovirus (CMV) and varicella zoster virus (VZV) clinical isolates to PNU-183792, a 4-oxo-dihydroquinoline, was examined. The antiviral potency of PNU-183792, a non-nucleoside inhibitor, was compared to the licensed nucleoside inhibitors ganciclovir and acyclovir using plaque reduction and virus yield reduction assays. PNU-183792 was as potent against CMV as ganciclovir and was superior in potency to acyclovir against VZV. PNU-183792 represents a new class of non-nucleoside inhibitors of human herpesviruses.

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