The influence of surface growth (two-dimensional microcarriers) and three-dimensional growth (aggregates and macroporous supports) in agitated, suspended batch culture systems upon growth and productivity of BHK was compared. Cultures using three porous microcarriers (CultiSpher G, Cellsnow EX, and
β¦ LIBER β¦
Comparative profiling of miRNA expression of lung adenocarcinoma cells in two-dimensional and three-dimensional cultures
β Scribed by Cui Li; Hong T. Nguyen; Yan Zhuang; Zhen Lin; Erik K. Flemington; Ying Zhuo; Stephen P. Kantrow; Gilbert F. Morris; Deborah E. Sullivan; Bin Shan
- Book ID
- 119241441
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 873 KB
- Volume
- 511
- Category
- Article
- ISSN
- 0378-1119
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## Abstract Growth in threeβdimensional (3D) architectures has been suggested to play an important role in tumor expansion and in the resistance of cancers to treatment with drugs or cytokines or irradiation. To obtain an insight into underlying molecular mechanisms, we addressed gene expression pr