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Comparative pharmacology of nicotine and ABT-418, a new nicotinic agonist

✍ Scribed by M. I. Damaj; K. R. Creasy; S. P. Welch; J. A. Rosecrans; M. D. Aceto; B. R. Martin


Publisher
Springer
Year
1995
Tongue
English
Weight
1002 KB
Volume
120
Category
Article
ISSN
0033-3158

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We describe herein the synthesis of various analogs of ABT-418, in which the stereogenic center is at the same time both quaternary and functional. The key step is the obtention of the aminoaldehyde la by means of ring contraction of the parent heterocyclic enamine.

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Pyrrolidines Bearing a Quaternary Ξ±-Stereogenic Center. Part 1. Synthesis of Analogues of ABT-418, a Powerful Nicotinic Agonist. -Starting with the pyridine derivative (I), the aminoaldehyde (VI) is synthesized as the key compound by ring contraction of the enamine (V). Standard procedures are used