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Comparative pharmacology of analogues of S-nitroso-N-acetyl-dl-penicillamine on human platelets

✍ Scribed by E. Salas; M.A. Moro; S. Askew; H.F. Hodson; A.R. Butler; M.W. Radomski; S. Moncada

Book ID
117960014
Publisher
Nature Publishing Group
Year
1994
Tongue
English
Weight
968 KB
Volume
112
Category
Article
ISSN
0007-1188

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The chemistries of S-nitroso-DL-penicillamine (SNAP) and S-nitrosoglutathione (GSNO) in relation to their ability to relax vascular smooth muscle and prevent platelet aggregation have been investigated. Metal ion catalysis greatly accelerates the decomposition of SNAP, but has little effect on GSNO.