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Comparative pharmacokinetics of paclitaxel after oral administration of Taxus yunnanensis extract and pure paclitaxel to rats

✍ Scribed by Jin, Jing; Cai, Dake; Bi, Huichang; Zhong, Guoping; Zeng, Hang; Gu, Lianquan; Huang, Zhiying; Huang, Min

Book ID
121290866
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
631 KB
Volume
90
Category
Article
ISSN
0367-326X

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## Abstract Paclitaxel is a substrate of the efflux transporters such as P‐glycoprotein, and is mainly metabolized by the liver. Schisandrol B (Sch B), one of the active components in Schisandra, has been reported to be able to inhibit the activity of P‐gp and CYP3A. It might be possible that Sch B