Serum drug levels following oral administration of large single doses of chlorphenesin carbamate and methocarbamol were fitted to a one-compartment open model. The appearance of each drug was described by a short lag time followed by a rapid first-order absorption and attainment of maximum levels. No statistically significant differences were found between estimates of mean lag times (to, 0.5 and 0.2 hr.), half-lives for absorption (tiln, 0.4 and 0.6 hr ), and times for attainment of maximum serum concentrations (t,,,, 1.9 and 1.4 hr.) for chlorphenesin carbamate and methocarbamol, respectively. Chlorphenesin carbamate was distributed throughout a significantly larger relative volume (1.27 uersus 0.48 l./kg.) and yielded a correspondingly smaller maximum serum concentration (15.3 uersus 29.8 mcg./ml., 2-g. dose). The mean biological half-life for chlorphenesin carbamate, 3.14 hr., was significantly greater than the value of 1.20 hr. obtained for methocarbamol.
Key phrases 0 Chlorphenesin carbamate-pharmacokinetic parameters, compared to methocarbamol, man [7 Methocarbamolpharmacokinetic parameters, compared to chlorphenesin carbamate, man c] Pharmacokinetic parameters-comparative, chlorphenesin carbamate and methocarbamol, man 0 Plasma levelscomparative, chlorphenesin carbamate and methocarbamol, man