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Comparative pharmacokinetics of [65Zn]Zinc sulfate and [65Zn]Zinc pantothenate injected intravenously in rabbits

โœ Scribed by Olivier Guillard; Philippe Courtois; Patrick Murai; Daniel Ducassou; Daniel Reiss

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
224 KB
Volume
73
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

The pharmacokinetics of zinc sulfate were compared with those of a new zinc salt, pantothenate, in rabbits. Each salt was administered at a dosage of 3.3 pCi of zinc-65/kg of bcdy weight. The measured pharmacokinetics of the two compounds responded to a two-compartment open model. The urinary elimination of the two salts was similar, as was their localization in the skin and fur, but zinc pantothenate was fixed by the liver to a lesser extent than war zinc sulfate.

Keyphrases 0 [65Zn]Zinc sulfate-intravenous administration to rabbits, pharmacokinetics 0 [6sZn]Zinc pantothenate-intravenous administration to rabbits, pharmacokinetics 0 Pharmacokinetics-comparison of [65%n]zinc sulfate and [6SZn)zinc pantothenate injected intravenously. rabbits D Zinc salts--iinc sulfate and zinc pantothenate, comparative pharmacokinetics, intravenous administration to rabbits

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