Comparative meta-analysis of adefovir dipivoxil monotherapy and combination therapy of adefovir dipivoxil and lamivudine for lamivudine-resistant chronic hepatitis B
โ Scribed by YongFa Chen; Ting Ju
- Book ID
- 118452164
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 1004 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1201-9712
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## Abstract Adefovir dipivoxil has been used alone or together with lamivudine to suppress lamivudineโresistant hepatitis B virus (HBV). However, the dynamics of HBV populations under different selection pressures and their impact on treatment outcome are poorly understood. Pyrosequencingยฎ was appl
Although adefovir dipivoxil (ADV) has a unique profile of delayed and infrequent resistance in treatment-naรฏve chronic hepatitis B patients, the association of ADV resistance with previous lamivudine (LAM) resistance is not well understood. We compared the emergence of the ADV-resistant mutations rt