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Comparative mass spectrometric analyses of Photofrin oligomers by fast atom bombardment mass spectrometry, UV and IR matrix-assisted laser desorption/ionization mass spectrometry, electrospray ionization mass spectrometry and laser desorption/jet-cooling photoionization mass spectrometry

✍ Scribed by Siegel, Marshall M.; Tabei, Keiko; Tsao, Rushung; Pastel, Michael J.; Pandey, Ravindra K.; Berkenkamp, Stefan; Hillenkamp, Franz; de Vries, Mattanjah S.

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 439 KB
Volume: 34
Category: Article
ISSN: 1076-5174
DOI: 10.1002/(sici)1096-9888(199906)34:6<661::aid-jms818>3.0.co;2-i

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✦ Synopsis

Photofrin (porfimer sodium) is a porphyrin derivative used in the treatment of a variety of cancers by photodynamic therapy. This oligomer complex and a variety of porphyrin monomers, dimers and trimers were analyzed with five different mass spectral ionization techniques: fast atom bombardment, UV and IR matrix-assisted laser desorption/ionization, electrospray ionization, and laser desorption/jet-cooling photoionization. All five approaches resulted in very similar oligomer distributions with an average oligomer length of 2.7 +/- 0.1 porphyrin units. In addition to the Photofrin analysis, this study provides a side-by-side comparison of the spectra for the five different mass spectrometric techniques.

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