𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Comparative genomic hybridization analysis of tonsillar cancer reveals a different pattern of genomic imbalances in human papillomavirus-positive and -negative tumors

✍ Scribed by Liselotte Dahlgren; Hanna Mellin; Danny Wangsa; Kerstin Heselmeyer-Haddad; Linda Björnestål; Johan Lindholm; Eva Munck-Wikland; Gert Auer; Thomas Ried; Tina Dalianis

Publisher
John Wiley and Sons
Year
2003
Tongue
French
Weight
627 KB
Volume
107
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Our aim was to map and compare genomic imbalances in human papillomavirus (HPV)‐positive and ‐negative squamous cell carcinomas of the tonsil. Twenty‐five primary carcinomas were analyzed by comparative genomic hybridization. Fifteen (60%) were found to be HPV‐positive by PCR, and the majority were HPV‐16. There were statistically significant differences in the distribution of DNA gains and losses between the HPV‐positive and ‐negative samples. Eleven of 15 HPV‐positive samples (73%) showed gain on chromosome 3q24‐qter, while only 4/10 (40%) HPV‐negative samples had the same gain (p = 0.049). Furthermore, 4/10 (40%) HPV‐negative samples but no HPV‐positive samples had gain on chromosome 7q11.2‐q22 (p = 0.017). As expected, and similar to previous studies, patients with an HPV‐positive tumor had a statistically significantly better disease‐specific survival than patients with an HPV‐negative tumor (p = 0.002). The most common changes, e.g., gain on 3q or 8q, loss on 11q or 13 and loss on chromosome 7q in HPV‐negative tumors, did not have any influence on prognosis. However the number of cases in each subgroup was limited. © 2003 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Comparative genomic hybridization analys
Comparative genomic hybridization analysis of human sarcomas: I. Occurrence of genomic imbalances and identification of a novel major amplicon at 1q21–q22 in soft tissue sarcomas
✍ Anne Forus; Daniël Olde Weghuis; Dominique Smeets; Øystein Fodstad; Ola Myklebos 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 624 KB

Comparative genomic hybridization (CGH) was recently developed as a tool to survey entire genomes for variations in DNA sequence copy numbers. We have applied this technique to detect and map amplified regions in 54 soft tissue sarcomas. Aberrations were detected by visual analysis of hybridization

Comparative gene expression profiling re
Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells
✍ Claudio Scafoglio; Concetta Ambrosino; Luigi Cicatiello; Lucia Altucci; Mario Ar 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 271 KB

## Abstract Antiestrogens used for breast cancer (BC) treatment differ among each other for the ability to affect estrogen receptor (ER) activity and thereby inhibit hormone‐responsive cell functions and viability. We used high‐density cDNA microarrays for a comprehensive definition of the gene pat

Imbalances of chromosome arm 1p in pedia
Imbalances of chromosome arm 1p in pediatric and adult germ cell tumors are caused by true allelic loss: A combined comparative genomic hybridization and microsatellite analysis
✍ Susanne Zahn; Sonja Sievers; Katayoun Alemazkour; Sandra Orb; Dieter Harms; Wolf 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 441 KB 👁 1 views

## Abstract Previous studies on childhood germ cell tumors (GCTs) report highly variable frequencies of losses at chromosome arm 1p. Since deletions at 1p portend a poor prognosis in other embryonal tumors, this study aims to clarify the question of the frequency of true allelic loss at 1p and whet