Comparative evaluation of various dissolution apparatus for capsule dosage forms

✍ Scribed by Song-Ling Lin; Johanne Menig; Charles J. Swartz

• Publisher: John Wiley and Sons
• Year: 1970
• Tongue: English
• Weight: 703 KB
• Volume: 59
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600590715

✦ Synopsis

The dissolution profiles of experimental diuretic and antidiabetic compounds in capsules were investigated by bead, plate, blade, holder. basket, disintegration time, and proposed USP dissolution methods. The apparent initial dissolution rate and the extent of drug released within the testing period were used as parameters in comparative evaluation of these seven methods. The influence of the size of the stirrer, the volume of dissolution medium, and the size of screen cloths for making the basket on the dissolution profile was studied and discussed. The Reynolds number of the fluid is introduced to explain the influence of the size of the stirrer on the dissolution rate. Due to the small screen (40 mesh) employed in the proposed USP dissolution method, the visual observation of the behavior of the capsule is impaired, and the chance of clogging the screen by the granules is greater than the self-designed (8 mesh) basket used in the basket method. The dissolution profiles obtained with the disintegration time method provide the fastest rate and the greatest extent of dissolution for both experiemental diuretic and antidiabetic compounds.