Rotating-flask method for dissolution-rate determinations of aspirin from various dosage forms

✍ Scribed by Howard Weintraub; Milo Gibaldi

• Publisher: John Wiley and Sons
• Year: 1970
• Tongue: English
• Weight: 522 KB
• Volume: 59
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600591218

✦ Synopsis

surface energy lev& of surfaces with only moderate polar forces would result in a very misleading estimate of at least the dispersion forces present in that surface.

Conclusions

It is possible to characterize tablet surfaces according to their CED by using contact-angle data and applying a modification of the Zisman (15) technique. However, caution must be exercised in the interpretation of the ye values obtained. Particular attention should be paid to the possible effects of unbalanced polar and dispersion forces between the test liquids and surfaces investigated.

The surface energy of a tablet, as well as the types of forces present, can to some extent be predicted by studying the types of chemical components that would be present at the surface.

More work needs to be done in determining the presence and relative roles of polar and dispersion forces as they influence wetting, contact-angle data, adsorption, and adhesion.

A knowledge of the types of forces acting across the interface between the tablet surface and a film coating, their relative intensities, and the degree of interaction should greatly advance the understanding of processes involved in the formation of an adequate film coating.