Comparative electrophysiological study of response to botulinum toxin type B in Japanese and Caucasians

✍ Scribed by Kimiyoshi Arimura; Yumiko Arimura; Yoshiharu Takata; Tomonori Nakamura; Ryuji Kaji

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 136 KB
• Volume: 23
• Category: Article
• ISSN: 0885-3185
• DOI: 10.1002/mds.21807

✦ Synopsis

Abstract

Ethnic differences in the muscle‐relaxing effect of botulinum toxin type B (BTX‐B) were examined by means of electrophysiological measurements in Japanese and Caucasian volunteers. This was a randomized, single‐blinded, single‐center study of 24 Japanese and 24 Caucasian healthy adult male subjects in Japan. BTX‐B (20 U, 100 U, or 500 U/0.2 mL) or placebo was administered to the extensor digitorum brevis (EDB) muscle in the left lower limb as a single dose (in each dose group, 6 subjects received the test drug and two received placebo). The inhibitory effect of BTX‐B on the M wave amplitude of EDB muscle generated by stimulation of the deep peroneal nerve was measured frequently during 2 weeks after administration, and then at weeks 4 (day 28) and 12 (day 84). The inhibitory effect of BTX‐B on the M wave amplitude of EDB muscle was dose‐dependent in both Japanese and Caucasian subjects, and the dose‐response curves were similar. These findings demonstrate that the muscle‐relaxing effect of BTX‐B in Japanese subjects is electrophysiologically similar to that in Caucasians. © 2007 Movement Disorder Society