In the face of growing chloroquine resistance of Plasmodium falciparum, efforts to prolong the clinical usefulness of the drug have partly concentrated on its combination with potential resistance-reversing compounds. However, clinical studies on such combinations have been limited. We have compared
Comparative Efficacy and Safety of Two Regimens of Chlorpheniramine plus Chloroquine in Acute Uncomplicated Falciparum Malaria in Children
โ Scribed by Prof. A. Sowunmi, A. D. A. Adedapo, F. A. Fehintola, C. O. Sowunmi, A. A. Adedeji, A. G. Falade, A. M. J. Oduola
- Book ID
- 119929590
- Publisher
- Springer International Publishing AG
- Year
- 2000
- Tongue
- English
- Weight
- 198 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1179-1918
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Chlorpheniramine, a histamine HI receptor antagonist, reverses chloroquine resistance in Plasmodium falciaarum in vitro. However. the clinical sianificance of this remains unclear. We have evaluated the efficacv of chloroquine and a chloroquine-chlorbheniramine combination in 112 consecutive childre
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