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Comparative effects of dextromethorphan and dextrorphan on nicotine discrimination in rats

โœ Scribed by M. Jerry Wright Jr.; Robert E. Vann; Thomas F. Gamage; M. Imad Damaj; Jenny L. Wiley


Book ID
113841168
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
338 KB
Volume
85
Category
Article
ISSN
0091-3057

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Sex differences in plasma half-life of d
โœ Gollamudi Ramachander; K. R. Bapatla; Jane Frances Emele ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 233 KB

Male and female rats exhibited striking differences in their ability to metabolize dextromethorphan. Upon oral administration of this drug, the plasma half-life of dextrorphan, a major biotransformation product formed by O-demethylation, was 40 min in the female rat and 18.5 min in the male.