The biochemical characteristics and the distribution of pituitary adenylate cyclaseactivating polypeptide (PACAP) binding sites have been investigated in the brain of the frog Rana ridibunda by using [ 125 I]PACAP27 as a radioligand. Membrane-binding studies revealed the existence of high-affinity r
Comparative distribution of pituitary adenylate cyclase-activating polypeptide (PACAP) binding sites and PACAP receptor mRNAs in the rat brain during development
β Scribed by Magali Basille; David Vaudry; Yolaine Coulouarn; Sylvie Jegou; Isabelle Lihrmann; Alain Fournier; Hubert Vaudry; Bruno Gonzalez
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 928 KB
- Volume
- 425
- Category
- Article
- ISSN
- 0021-9967
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Pituitary adenylate cyclase activating polypeptide (PACAP) was isolated from ovine hypothalamus and known to stimulate the production of cAMP in anterior pituitary cells. In the recent report, the expression of PACAP was detected in preovulatory follicles, and treatment with PACAP stimulated the pro
It has been demonstrated that pituitary adenylate cyclase activating polypeptide (PACAP) promotes the survival of neurons in culture and can inhibit neuronal cell death after experimental injury. Furthermore, peripheral axotomy results in increased PACAP gene expression in sensory and sympathetic ne
## Abstract Pituitary adenylate cyclaseβactivating polypeptide (PACAP), a neurotrophic and neuromodulatory peptide, was recently shown to enhance NMDA receptorβmediated currents in the hippocampus (Macdonald, et al. 2005. J Neurosci 25:11374β11384). To check if PACAP might also modulate AMPA recept