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Comparative cytotoxicity and pharmacokinetics of antimelanoma immunotoxins containing either natural or recombinant gelonin

โœ Scribed by Michael G. Rosenblum; John W. Marks; Lawrence H. Cheung

Book ID
105994546
Publisher
Springer
Year
1999
Tongue
English
Weight
120 KB
Volume
44
Category
Article
ISSN
0344-5704

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lmmunotoxins were constructed by attaching native ricin A chain, ricin A, chain and recombinant r i c h A chain to the mouse monoclonal IgG,, antibody Fib75 by means of a disulphide linkage using the hetero-bifunctional cross-linker SPDP. The Fib75 immunotoxins were of similar composition and exerte