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Comparative analysis ofHomo sapiensandMus musculuscyclin-dependent kinase (CDK) inhibitor genes P16 (MTS1) and P15 (MTS2)

✍ Scribed by Ping Jiang; Steven Stone; Roger Wagner; Susan Wang; Priya Dayananth; Christine A. Kozak; Barbara Wold; Alexander Kamb

Book ID
104651266
Publisher
Springer
Year
1995
Tongue
English
Weight
909 KB
Volume
41
Category
Article
ISSN
0022-2844

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✦ Synopsis

Cyclin-dependent kinase inhibitors are a growing family of molecules that regulate important transitions in the cell cycle. At least one of these molecules, p16, has been implicated in human tumorigenesis while its close homolog, p15, is induced by cell contact and transforming growth factor-[3 (TGF-[3). To investigate the evolutionary and functional features of p15 and p16, we have isolated mouse (Mus musculus) homologs of each gene. Comparative analysis of these sequences provides evidence that the genes have similar functions in mouse and human. In addition, the comparison suggests that a gene conversion event is part of the evolution of the human p15 and p16 genes.

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## Abstract Cyclin and cyclin‐dependent kinase (a) complexes play important roles in modulating the cell cycle. The CDK inhibitors (a) inhibit the kinase activities of these complexes and block the cell cycle. The __p16__/multiple tumor suppressor (__MTS__) 1/inhibitor of CDK4 (__INK4__) a/__CDKN2_